The Vaccine Manufacturing Research Hub (VaxHub) is a network co-led by University College London and the University of Oxford, bringing together academia, industry, and non-governmental organisations. The network is comprised of Vax-Hub Global and Vax-Hub Sustainable. Vax-Hub Global aims to create flexible, low-cost vaccine platforms for deployment in low- and middle-income countries (LMICs), while Vax-Hub Sustainable focuses on developing new tools and technologies to accelerate vaccine manufacturing and improve distribution, storage, and environmental sustainability. In this talk, an overview of the Hub’s mechanisms, research, outreach, and policy activities will be presented, along with case studies that demonstrate effective process development for new vaccines.