The development and manufacturing of vaccines has rich history and evolution, driving, adopting or adapting the science and technology boundaries of the time. As a vaccine progresses through the life cycle, from discovery to stablished product to end of life cycle, different factors dictate the decisions and paths organizations take. From the constraints of the scientific and technical knowledge, to the economics of production and distribution, our industry achieves a careful balance to ensure the continued delivery of life-saving vaccines. In this presentation, we will look through the lens of the manufacturer at factors playing significant roles as a vaccine candidate transitions from development to commercial manufacturing, from launch to mature product incorporating advances in science, technology and regulatory science and to a final transition at the end of the product life cycle.