The Future Vaccine Manufacturing Research Hub (Vax-Hub) is a partnership between academia, industry and non-government organizations aimed at the development, scale up and manufacture of vaccines for LMIC. In this talk an overview of the Hub mechanism, outcomes and research activities will be presented, as well as a case study focusing on a promising Protein-Glycan Coupling technology (PGCT) and the science-based approach used to speed up the process development of a new vaccine.