Global Health agencies have relied on vaccination as one of the most effective treatment options during epidemics and more recently pandemics associated with viral disease. Vaccination campaigns have been shown to significantly reduce the number of deaths caused by infectious agents. With the introduction of cell culture and DNA recombinant technologies vaccine design has changed dramatically. Permissive cell lines have allowed the production of attenuated and inactivated vaccines. The advent and use of newer manufacturing technologies to produce vaccines though the use of, for example, virus like particles, vectored vaccines and chimeric vaccines bring specific quality and safety issues which need to be addressed. The overall safety of vaccines is still of paramount importance and this presentation will focus on regulatory expectations from a global view. In addition, we will address the impact of new vaccine developments which are now being used to supply high quality and effective products.